The Wittig approach was generally used to prepare the RSV core by employing the proper slides. These hybrid compounds displayed anticancer, anti-inflammatory, antioxidant, anti-Alzheimer, metal chelating, and enzyme inhibitory properties. These hybrid RSV molecules might be used as lead compounds in the development of novel therapeutic molecules in the future.
Resveratrol (RSV) is a naturally occurring polyphenol that is generated by several plant species and has a wide range of biological actions. It may be found in a variety of foods and drinks, including mulberries, peanuts, grapes, apples, plums, and red wine. Plants manufacture it as a protective chemical to defend themselves from environmental or insect harm.
RSV exists in two stereo isomeric forms: cis and trans. The trans isomer is the more common and physiologically active. RSV affects multiple systems in the body and is hence classified as a multimarket molecule. RSV was shown to have anti-inflammatory, anticancer, antioxidant, cardio protective, and chemo preventive activities.
It suppresses cancer cell growth without causing harm to normal cells10. RSV is a hydrophilic molecule with three hydroxyl groups (hybridresvera), and its half life is short 8-14 minutes, limiting its bioavailability and potency. Current RSV modifications address both the enhancement of pharmacokinetic features and the improvement of pharmacological activity.
Various approaches have been used to create RSV variants with various sorts of activity. Recently, there has been a lot of interest in the design of hybrid compounds that have two pharmacophores in one molecule.
Depending on the inclusion of beginning molecules, hybrid molecules are classed as linked, merged, or fused. Using hybrid molecular methods, RSV has also been coupled with other physiologically active molecules. RSV hybrid molecules displayed a wide range of actions.
In this study, we attempted to describe the synthetic techniques employed for hybrid RSV molecules as well as the biological activities displayed by them.
RSV hybrid molecules with other natural compounds
RSV hybrid molecules were created by combining RSV with bioactive natural substances such as coumarin, chalcone, and caffeic acid. As an antioxidant, coumarin and RSV hybrid molecules were produced. For 16 hours, 2-hydroxy-4-acetoxy benzaldehyde was refluxed with 3-acetoxy phenyl acetic acid in acetic anhydride.
Following the first process, acetoxy-3-phenyl Coumadin is formed. The final chemical, hydroxy-3-phenyl Coumadin, was produced in 90-94 percent yield using the hydrolysis procedure. Compound 5 was the most potent antioxidant in this series (54 percent as a scavenger of hydroxyl free radicals). The presence of two hydroxyl groups in the molecule is ideal for the molecule’s action. As a result, it can operate as an inhibitor of free radical overproduction.
RSV hybrid molecules have been created utilising approaches such as fused hybrid and merged hybrid. RSV was linked to other molecules in certain situations through a linker group. The primary core of RSV was largely synthesised via the Wittig process and aldol condensation reactions. RSV hybridization with natural compounds such as coumarin, chalcones, and caffeic acid shown anticancer activity.
RSV hybrid compounds with cur cumin, chaconne, and salicylates displayed anti-inflammatory action. Salicylates and RSV hybrid molecules inhibited the CYP1A1 and DNMT3 enzymes as well. Antioxidant capabilities were observed in RSV and vitamin E hybrid molecules. RSV hybrid compounds with vitamin B6, clioquinol, tacrine, and deferiprone exhibited anti-alzheimer characteristics, suggesting that they might be used as lead molecules in the treatment of Alzheimer’s disease. Also visit