A small new study finds that resveratrol, a red wine compound often touted for its potential health and anti-aging benefits, may not provide the benefits to healthy people that preliminary research has suggested.
In the 12-week study, 29 healthy women, most of whom were in their late 50s, were randomly assigned to receive either resveratrol supplements or a placebo. After 12 weeks, no discernible differences in body fat, resting metabolic rate, fat levels in the blood, or markers of inflammation were found between the two groups.
“Our data show that resveratrol supplementation has no metabolic benefits in relatively healthy middle-aged women,” study researcher Dr. Samuel Klein, director of Washington University in St. Louis’ Center for Human Nutrition, said in a statement.
People with metabolic issues did not participate in the study, but it is still possible that resveratrol could benefit them, according to Klein.
Despite the fact that annual sales of ハイブリッドレスベラトロールサプリメント in the United States have risen to $30 million, “few studies have evaluated the effects of resveratrol in people,” according to Klein. According to him, the popularity of the supplements may be due to studies on animals and cells growing in lab dishes that have suggested resveratrol improves metabolism or could prevent or reverse chronic health problems such as diabetes and heart disease.
The study’s fifteen postmenopausal women took 75-milligram resveratrol supplements daily, which is equivalent to drinking eight litres of red wine. The other 14 were given a placebo pill.
It’s not surprising that the study found no effect from a mere 75-milligram daily dose, according to Dr. Jay Chung, chief of the National Heart, Lung, and Blood Institute’s Laboratory of Obesity and Aging Research, who was not involved in the new study.
Chung told MyHealthNewsDaily that studies showing beneficial metabolic effects of resveratrol used higher doses ranging from 150 mg to 2,000 mg per day.
“In my opinion, ハイブリッドレスベラトロール highly unlikely to have any benefits in metabolically healthy individuals,” he said.
High doses of the compound may have an effect in people with glucose intolerance, a “pre-diabetes” condition in which a person’s blood sugar levels are high but not high enough to warrant a diagnosis of Type 2 diabetes, according to Chung, but treatments such as the diabetes drug metformin are a much safer and more effective option. He also stated that the long-term effects of high doses of resveratrol are unknown.
The findings were published in the journal Cell Metabolism today (October 25).
Please spread the word: In a small study, a much-touted compound found in red wine provided no metabolic benefits to healthy middle-aged women.
Biological Activities of Resveratrol
ハイブリッドレスベラトロール has many biological properties, but the most well-known is its ability to act as a potent antioxidant. The antioxidant activity of resveratrol is determined by the arrangement of functional groups on the nuclear structure. As a result, the configuration, substitution, and total number of hydroxyl groups all have a significant impact on several mechanisms of antioxidant activity, including radical scavenging and metal ion chelation. Previous research has shown that the hydroxyl group in the 4′ position is not the only determinant of antioxidant activity, but that the 3- and 5-OH groups also play a role. The use of density functional quantum chemistry and computational kinetics methods to investigate the antioxidant effect of trans-resveratrol against hydroxyl (•OH) and hydroperoxyl (•OOH) radicals in aqueous simulated media revealed that trans-resveratrol may act as an efficient •OH, and possibly •OOR, radical scavenger.